Death associated protein kinase

By Targets:	DAPK (3) Apoptosis (2) Autophagy (2) Casein Kinase (1) Epigenetic Reader Domain (1) RIP kinase (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (2)

Targets Recommended: DAPK PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15847

HS38 1 Publications Verification	DAPK	Cardiovascular Disease
HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and *zipper-interacting protein* kinase (ZIPK, also called DAPK3), with K_ds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC₅₀** of 200 nM. HS38 can be used for the research of smooth muscle related disorders .

HY-P1344A

DAPK Substrate Peptide TFA

DAPK Cancer

DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a K_m of 9 μM .

DAPK Substrate Peptide TFA	DAPK	Cancer
DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a K_m of 9 μM .

HY-149006

CK156	DAPK	Inflammation/Immunology Cancer
CK156 is a highly selective death-associated protein kinase (DAPK) inhibitor with IC₅₀s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases .

HY-138779

ICCB-19 hydrochloride	Autophagy RIP kinase Apoptosis	Inflammation/Immunology
ICCB-19 hydrochloride is a *TRADD (TNFRSF1A associated* via death domain)** inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins .

HY-145260

BRD4/CK2-IN-1	Epigenetic Reader Domain Casein Kinase Apoptosis Autophagy	Cancer
BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC₅₀s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and *autophagy*-associated cell death in triple-negative breast cancer (TNBC)

Cat. No.	Product Name

HY-L075

Anti-Lung Cancer Compound Library	1835 compounds
Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 1835 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Anti-Lung Cancer Compound Library

1835 compounds

Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers.

As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy.

MCE offers a unique collection of 1835 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P1344A

DAPK Substrate Peptide TFA

DAPK Cancer

DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a K_m of 9 μM .
HY-P1344

DAPK Substrate Peptide

Peptides Cancer

DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a K_m of 9 μM .

DAPK Substrate Peptide TFA	DAPK	Cancer
DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a K_m of 9 μM .

DAPK Substrate Peptide	Peptides	Cancer
DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a K_m of 9 μM .

Species:	Human (6)
Tag:	His (2) Tag Free (2) GST (4)
Source:	Sf9 insect cells (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P76858

	DAPK1 Protein, Human (sf9, His-GST) Death-associated protein kinase 1; DAP kinase 1; DAPK	Human	Sf9 insect cells
	The DAPK1 protein is a calcium/calmodulin-dependent kinase involved in multiple cellular pathways, regulating cell survival, apoptosis, and autophagy. The DAPK1 protein also acts as a signal amplifier for NMDA receptors, causing brain damage in stroke. DAPK1 Protein, Human (sf9, His-GST) is the recombinant human-derived DAPK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of DAPK1 Protein, Human (sf9, His-GST) is 363 a.a., with molecular weight of ~64 kDa.

HY-P702657

DAPK1 Protein, Human (289a.a, sf9, GST)

Death-associated protein kinase 1; DAP kinase 1; DAPK
Human Sf9 insect cells

HY-P77286

	DAPK3/ZIPK Protein, Human (sf9, GST) Death-associated protein kinase 3; DAP kinase 3; Dlk; MYPT1 kinase; ZIPK	Human	Sf9 insect cells
	The DAPK3/ZIPK protein is a multifunctional serine/threonine kinase that complexly regulates apoptosis, autophagy, transcription, translation, and actin cytoskeletal reorganization. Its key roles include coordinating apoptotic and autophagy signaling, influencing smooth muscle contraction, and regulating starvation-induced autophagy. DAPK3/ZIPK Protein, Human (sf9, GST) is the recombinant human-derived DAPK3/ZIPK protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of DAPK3/ZIPK Protein, Human (sf9, GST) is 454 a.a., with molecular weight of ~70 kDa.

HY-P702658

DAPK2 Protein, Human (sf9, His, GST)

DAPK2; Death associated protein kinase 2; DRP1; DRP-1
Human Sf9 insect cells

HY-P702659

	STK17A Protein, Human (sf9) STK17A; serine/threonine kinase 17a; serine/threonine kinase 17a (apoptosis inducing); serine/threonine-protein kinase 17A; Death associated protein kinase related 1; DRAK1; Death-associated protein kinase-related 1; serine/threonine kinase 17a (apoptosis-inducing); DAP kinase-related apoptosis-inducing protein kinase 1	Human	Sf9 insect cells

HY-P701363

	CDK19-CCNC-MED12 Protein, Human (Sf9) CDK19; CCNC; MED12; Cyclin-dependent kinase 19; CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein	Human	Sf9 insect cells
	CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication. CDK19-CCNC-MED12 Protein, Human (Sf9) is the recombinant human-derived CDK19-CCNC-MED12 protein, expressed by Sf9 insect cells , with tag free. ,


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Cat. No.	Product Name	Application	Reactivity

HY-P83053

DAP Kinase 1 Antibody (YA2798) DAK1; DAP K1; DAP kinase 1; DAPK 1; DAPK; DAPK1; DAPK1_HUMAN; Death associated protein kinase 1; Death-associated protein kinase 1	WB, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P82898

DAPK2 Antibody (YA2643)

DAPK2; Death-associated protein kinase 2; DAP kinase 2; DAP-kinase-related protein 1; DRP-1
WB, IHC-P Rat
HY-P83574

DAP kinase 3 Antibody (YA3319)

DAPK3; ZIPK; Death-associated protein kinase 3; DAP kinase 3; DAP-like kinase; Dlk; MYPT1 kinase; Zipper-interacting protein kinase; ZIP-kinase
WB Human

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